Soo-gaadhista pyrethroids waxay kordhin kartaa khatarta cudurka Parkinson sababtoo ah isdhexgalka hidde-sideyaasha iyada oo loo marayo habdhiska difaaca jirka.
Pyrethroids waxaa laga helaa ganacsiyada badankoodCayayaanka guryaha lagu buufiyoIn kasta oo ay sun u yihiin cayayaanka, haddana guud ahaan waxaa loo arkaa inay yihiin kuwo ammaan u ah taabashada aadanaha iyadoo ay ugu wacan tahay mas'uuliyiinta federaalka.
Kala duwanaanshaha hidde-sidaha iyo soo-gaadhista sunta cayayaanka ayaa u muuqda inay saameyn ku leeyihiin khatarta cudurka Parkinson. Daraasad cusub ayaa heshay xiriir ka dhexeeya labadan arrimood ee khatarta ah, taasoo muujinaysa doorka jawaabta difaaca jirka ee horumarka cudurka.
Natiijooyinka waxay la xiriiraan fasalsunta cayayaankaloo yaqaan pyrethroids, kuwaas oo laga helo inta badan cayayaanka guryaha ganacsiga ah waxaana si isa soo taraysa loogu isticmaalaa beeraha iyadoo cayayaanka kale la joojiyo. In kasta oo pyrethroids ay sun u yihiin cayayaanka, haddana mas'uuliyiinta federaalku guud ahaan waxay u arkaan inay yihiin kuwo ammaan ah oo loogu talagalay soo-gaadhista aadanaha.
Daraasaddu waa tii ugu horreysay ee isku xirta soo-gaadhista pyrethroid-ka iyo khatarta hidde-sidaha ee cudurka Parkinson waxayna u baahan tahay daraasado dabagal ah, ayuu yiri qoraaga sare Malu Tansi, Ph.D., kaaliyaha borofisar ku takhasusay cilmiga fiisigiska ee Jaamacadda Emory School of Medicine.
Kala duwanaanshaha hidde-sidaha ee kooxdu ay ogaatay wuxuu ku jiraa gobolka aan codeyn ee hiddo-sidayaasha MHC II (heerka isku-dhafka histocompatibility ee ugu weyn fasalka II), oo ah koox hiddo-sidayaal ah oo nidaamiya habdhiska difaaca jirka.
"Ma aanan fileynin inaan helno xiriir gaar ah oo lala yeesho pyrethroids," ayuu yiri Tansey. "Waa la ogyahay in soo-gaadhista degdegga ah ee pyrethroids ay sababi karto cillad difaac, molecules-ka ay ku dhaqmaanna waxaa laga heli karaa unugyada difaaca jirka; Hadda waxaan u baahanahay inaan wax badan ka fahanno sida soo-gaadhista muddada dheer ay u saamayso habdhiska difaaca jirka sidaas darteedna ay u xoojiso shaqadiisa." Khatarta cudurka Kinson."
"Waxaa horey u jiray caddeymo xooggan oo muujinaya in bararka maskaxda ama habdhiska difaaca jirka oo aad u firfircoon uu gacan ka geysan karo horumarka cudurka Parkinson. "Waxaan u maleyneynaa in waxa halkan ka dhacaya ay tahay in soo-gaadhista deegaanka ay bedeli karto jawaabta difaaca jirka ee dadka qaar, taasoo kor u qaadaysa bararka daba-dheeraada ee maskaxda."
Daraasaddan, cilmi-baarayaasha Emory oo ay hoggaaminayeen Tansey iyo Jeremy Boss, Ph.D., oo ah guddoomiyaha Waaxda Microbiology iyo Immunology, ayaa la shaqeeyay Stuart Factor, Ph.D., agaasimaha Xarunta Cudurrada Parkinson ee Emory, iyo Beate Ritz., MD, Jaamacadda California, San Francisco. Iyadoo lala kaashanayo cilmi-baarayaasha caafimaadka dadweynaha ee UCLA, Ph.D. Qoraaga ugu horreeya ee maqaalka waa George T. Kannarkat, MD.
Cilmi-baarayaasha UCLA waxay isticmaaleen xog ururin juqraafiyeed oo California ah oo daboolaysa 30 sano oo isticmaalka sunta cayayaanka ah ee beeraha. Waxay go'aamiyeen soo-gaadhista iyadoo lagu saleynayo masaafada (shaqada qof iyo cinwaanada guriga) laakiin ma aysan cabbirin heerarka sunta cayayaanka ee jirka. Pyrethroids waxaa loo maleynayaa inay si dhakhso ah u burburaan, gaar ahaan marka ay la kulmaan iftiinka qorraxda, iyadoo nus-nololeedkoodu uu ku jiro ciidda maalmo ilaa toddobaadyo.
962 qof oo ka yimid Dooxada Dhexe ee California, nooc caadi ah oo MHC II ah oo ay weheliso soo-gaadhista sunta cayayaanka ee pyrethroid ayaa kordhisay khatarta cudurka Parkinson. Nooca ugu khatarta badan ee hidda-wadaha (dadka sita laba alleles oo halis ah) ayaa laga helay 21% bukaannada qaba cudurka Parkinson iyo 16% kuwa la xakameeyo.
Kooxdan, soo-gaadhista hidda-wadaha ama pyrethroid-ka keliya si weyn uma kordhin khatarta cudurka Parkinson, laakiin isku-darka ayaa sameeyay. Marka la barbardhigo celceliska, dadka la kulmay pyrethroid-yada oo sitay nooca ugu khatarta badan ee hidda-wadaha MHC II waxay lahaayeen khatar 2.48 jeer ka badan oo ah inay qaadaan cudurka Parkinson marka loo eego kuwa aan soo-gaadhista badnayn waxayna siteen nooca ugu khatarta yar ee hidda-wadaha. Soo-gaadhista noocyada kale ee sunta cayayaanka, sida organophosphates ama paraquat, si la mid ah uma kordhiso khatarta.
Daraasado hidde-side oo waaweyn, oo ay ku jiraan Factor iyo bukaannadiisa, ayaa hore ugu xiray kala duwanaanshaha hidde-sideyaasha MHC II cudurka Parkinson. Waxaa la yaab leh, kala duwanaanshaha hidde-sideyaasha isku mid ah ayaa si kala duwan u saameeya khatarta cudurka Parkinson dadka Caucasian/Yurub iyo dadka Shiinaha. Hidde-sideyaasha MHC II aad bay ugu kala duwan yihiin shakhsiyaadka; sidaas darteed, waxay door muhiim ah ka ciyaaraan xulashada xubnaha la tallaalay.
Tijaabooyin kale ayaa muujiyay in kala duwanaanshaha hidde-sidaha ee la xiriira cudurka Parkinson ay la xiriiraan shaqada unugyada difaaca jirka. Cilmi-baarayaashu waxay ogaadeen in 81 bukaan oo qaba cudurka Parkinson iyo kantaroolada Yurub ee Jaamacadda Emory, unugyada difaaca jirka ee dadka qaba noocyada hidde-sidaha MHC II ee khatarta sare leh ee daraasadda California ay muujiyeen molecules MHC oo badan.
Molecules-ka MHC waxay saldhig u yihiin habka "soo bandhigidda antigen-ka" waana xoogga kiciya ee kiciya unugyada T isla markaana ku lug leh inta kale ee habdhiska difaaca jirka. Muujinta MHC II waxay ku korodhaa unugyada deggan ee bukaanada qaba cudurka Parkinson iyo xakamaynta caafimaadka qaba, laakiin jawaab celin weyn oo ku saabsan caqabadda difaaca jirka ayaa lagu arkay bukaanada qaba cudurka Parkinson ee leh hiddo-sidayaasha khatarta sare leh;
Qorayaashu waxay soo gabagabeeyeen: "Xogtayadu waxay soo jeedinaysaa in biomarkers-ka unugyada, sida kicinta MHC II, ay ka faa'iideysan karaan molecules-ka milma ee ku jira plasma iyo dareeraha cerebrospinal si loo aqoonsado dadka khatarta ugu jira cudurka ama loo qoro bukaanada si ay uga qayb qaataan tijaabooyinka daawooyinka difaaca jirka." "Tijaabo."
Daraasaddan waxaa taageeray Machadka Qaranka ee Xanuunnada neerfaha iyo Faaliga (R01NS072467, 1P50NS071669, F31NS081830), Machadka Qaranka ee Sayniska Caafimaadka Deegaanka (5P01ES016731), Machadka Qaranka ee Sayniska Caafimaadka Guud (GM47310), Hay'adda Qoyska Sartain Lanier, iyo Hay'adda Michael J. Foxpa Kingson ee Cilmi-baarista Cudurrada.
Waqtiga boostada: Juun-04-2024