Soo-gaadhista pyrethroids waxay kordhin kartaa halista cudurka Parkinson sababtoo ah isdhexgalka hidde-sideyaasha iyada oo loo marayo habka difaaca jirka.
Pyrethroids waxaa laga helaa inta badan ganacsigasunta cayayaanka guriga.Inkasta oo ay neurotoxic ku yihiin cayayaanka, guud ahaan waxaa loo arkaa inay badbaado u yihiin xiriirka bini'aadamka ee maamulka federaalka.
Kala duwanaanshaha hidde-sideyaasha iyo soo-gaadhista sunta cayayaanka ayaa u muuqda inay saameeyaan halista cudurka Parkinson.Daraasad cusub ayaa ogaatay xiriirka ka dhexeeya labadan arrimood ee khatarta ah, taas oo muujinaysa doorka difaaca jirka ee horumarka cudurka.
Natiijadu waxay la xidhiidhaa fasalkasunta cayayaankaloo yaqaan pyrethroids, kuwaas oo laga helo inta badan sunta cayayaanka guryaha ee ganacsiga waxaana si sii kordheysa loogu isticmaalo beeraha maadaama ay meesha ka baxeen suntii kale.Inkasta oo pyrethroids ay yihiin kuwo neurotoxic ah cayayaanka, mas'uuliyiinta federaalku waxay guud ahaan u tixgeliyaan inay ammaan u yihiin soo-gaadhista aadanaha.
Daraasadu waa tii ugu horeysay ee isku xirta soo-gaadhista pyrethroid ee khatarta hidde ee cudurka Parkinson waxayna dammaanad qaadaysaa daraasado dabagal ah, ayuu yidhi qoraaga sare ee Malu Tansi, Ph.D., kaaliyaha borofisar ku takhasusay physiology at Emory University School of Medicine.
Kala duwanaanshiyaha hidde ee kooxda la ogaaday waa gobolka aan codeeyn ee MHC II (Histocompatibility complex class II), koox hidde-side ah oo nidaamisa nidaamka difaaca.
"Ma aanan fileyn inaan helno xiriir gaar ah oo ku saabsan pyrethroids," Tansey ayaa sidaas yidhi."Waxaa la og yahay in soo-gaadhista degdega ah ee loo yaqaan 'pyrethroids' ay sababi karto shaqada difaaca jirka, molecules-ka ay ku shaqeeyaan waxaa laga heli karaa unugyada difaaca;Waxaan hadda u baahanahay inaan wax badan ka fahanno sida soo-gaadhista muddada-dheer ay u saamayso habka difaaca jirka oo ay kor ugu qaaddo shaqadiisa.Khatarta cudurka Kinson."
"Waxaa mar horeba jiray caddaymo xooggan oo muujinaya in bararka maskaxda ama habka difaaca jirka oo badan uu gacan ka geysan karo horumarka cudurka Parkinson."Waxaan u maleyneynaa in waxa halkan ka dhacaya ay tahay in soo-gaadhista deegaanku ay bedeli karto jawaabta difaaca ee dadka qaarkood, kor u qaadida bararka joogtada ah ee maskaxda."
Daraasadda, cilmi-baarayaasha Emory oo ay hogaaminayaan Tansey iyo Jeremy Boss, Ph.D., oo ah guddoomiyaha Waaxda Microbiology iyo Immunology, waxay la midoobeen Stuart Factor, Ph.D., agaasimaha Emory's Comprehensive Parkinson's Disease Center, iyo Beate Ritz., MD, Jaamacadda California, San Francisco.Iyadoo lala kaashanayo cilmi-baarayaasha caafimaadka dadweynaha ee UCLA, Ph.D.Qoraaga koowaad ee maqaalku waa George T. Kannarkat, MD.
Cilmi-baarayaasha UCLA waxay adeegsadeen xogta juqraafiga California oo daboolaysa 30 sano ee isticmaalka sunta cayayaanka ee beeraha.Waxay go'aamiyeen soo-gaadhis ku salaysan fogaanta (shaqada qof iyo cinwaanada guriga) laakiin ma aysan cabbirin heerarka sunta cayayaanka ee jirka.Pyrethroids ayaa loo malaynayaa inay si dhakhso ah u hoos u dhacaan, gaar ahaan marka ay la kulmaan iftiinka qorraxda, oo leh nolol nus ah oo ciidda maalmo ilaa toddobaadyo ah.
Waxaa ka mid ah 962 maaddo oo ka yimid Dooxada Dhexe ee California, kala duwanaansho caadi ah oo MHC II ah oo ay weheliso soo-gaadhista celceliska ka sarreeya ee sunta cayayaanka ee pyrethroid waxay kordhisay khatarta cudurka Parkinson.Nooca ugu khatarta badan ee hidda-wadaha (shakhsiyaadka sidda laba alleles oo halis ah) ayaa laga helay 21% bukaannada qaba cudurka Parkinson iyo 16% kontaroolada.
Kooxdan, soo-gaadhista hidda-wadaha ama pyrethroid kaliya si weyn uma kordhin khatarta cudurka Parkinson, laakiin isku-darka ayaa sameeyay.Marka la barbardhigo celceliska, dadka la kulmay pyrethroids oo qaaday qaabka ugu khatarta badan ee hidda-wadaha MHC II ayaa 2.48 jeer ka khatar badan inuu ku dhaco cudurka Parkinson marka loo eego kuwa leh khatarta ugu yar ee hidda-wadaha.khatarta.Soo-gaadhista noocyada kale ee sunta cayayaanka, sida organophosphates ama paraquat, ma kordhiso khatarta si la mid ah.
Daraasado waaweyn oo hidde-raac ah, oo ay ku jiraan Factor iyo bukaannadiisa, ayaa hore ugu xidhay kala duwanaanshaha hidda-wadaha MHC II iyo cudurka Parkinson.Waxaa la yaab leh, kala duwanaanshaha hidde-sideyaasha ayaa si kala duwan u saameeya halista cudurka Parkinson ee dadka Caucasians/Yurub iyo dadka Shiinaha.Hidde-sidayaasha MHC II aad bay ugu kala duwan yihiin shakhsiyaadka;sidaas darteed, waxay door muhiim ah ka ciyaaraan xulashada xubnaha taranka.
Tijaabooyin kale ayaa muujiyay in kala duwanaanshaha hidda-socodka ee la xidhiidha cudurka Parkinson ay la xiriiraan shaqada unugyada difaaca.Cilmi-baadhayaashu waxay ogaadeen in 81 ka mid ah bukaannada cudurka Parkinson iyo kontaroolada Yurub ee Jaamacadda Emory, unugyada difaaca ee dadka khatarta sare leh ee MHC II ee kala duwanaanshiyaha California waxay muujiyeen molecules MHC badan.
Unugyada MHC waxay hoosta ka xariiqayaan habka "soo bandhigida antigen-ka" waana awooda dhaqaajinta ee dhaqaajisa unugyada T oo ku lug leh habka difaaca intiisa kale.Muujinta MHC II waxay ku korodhay unugyada quiescent ee bukaanka cudurka Parkinson iyo kontaroolada caafimaadka qaba, laakiin jawaab celin weyn oo ku saabsan caqabada difaaca ayaa lagu arkay bukaanka cudurka Parkinson ee leh genotypes halis sare leh;
Qorayaashu waxay soo gabagabeeyeen: "Xogtayadu waxay soo jeedinaysaa in biomarkers-ka gacanta, sida firfircoonida MHC II, laga yaabo inay ka faa'iido badan tahay molecules-ka milmay ee plasma iyo dareeraha cerebrospinal si loo aqoonsado dadka khatarta ugu jira cudurka ama qorista bukaanada si ay uga qaybqaataan tijaabooyinka daawooyinka immunomodulatory.""Tijaabi."
Daraasada waxaa taageeray Machadka Qaranka ee Xanuunada Neerfaha iyo Stroke (R01NS072467, 1P50NS071669, F31NS081830), Machadka Qaranka ee Sayniska Caafimaadka Deegaanka (5P01ES016731), Machadka Qaranka ee Sayniska Caafimaadka Guud ee Qoyska (GM47310), Sartain. Michael J. Foxpa Kingson Foundation ee Cilmi-baarista Cudurrada.
Waqtiga boostada: Jun-04-2024